People who carry the APOE e4 form of the APOE gene appear to have a higher risk of serious brain-swelling and brain-bleeding complications from lecanemab or donanemab, and the FDA recommends testing for this gene before treatment.
Sources
- Dementia - Diagnosis and treatment (mayoclinic.org)
- https://www.fda.gov/news-events/press-announcements/fda-converts-novel-alzheimers-disease-treatment-traditional-approval (fda.gov)
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761269Orig1s001lbl.pdf (accessdata.fda.gov)
- https://www.ncbi.nlm.nih.gov/books/NBK605938/ (ncbi.nlm.nih.gov)
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180672/ (ncbi.nlm.nih.gov)
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