The FDA recommends a brain MRI before starting lecanemab or donanemab and periodic brain MRIs during treatment to monitor for brain swelling or bleeding.
Sources
- Dementia - Diagnosis and treatment (mayoclinic.org)
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/761248s004lbl.pdf (accessdata.fda.gov)
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/761269s013lbl.pdf (accessdata.fda.gov)
- https://www.fda.gov/drugs/drug-safety-communications/fda-recommend-additional-earlier-mri-monitoring-patients-alzheimers-disease-taking-leqembi-lecanemab (fda.gov)
- https://kisunla.lilly.com/hcp/dosing-monitoring (kisunla.lilly.com)
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